We know you've tried other antidepressant drugs before_ sometimes it's hard to know if you have the best answer right in front of you, but give Zoloft a chance. It affects serotonin in your brain differently than most medications for Azithromycin 500 mg depression, and it may be just what you need to feel better again. You can read more about how it works here, or Azithromycin 500 mg try it out for yourself!