Because of its effects on serotonin and norepinephrine, Zoloft is more effective than other antidepressants for some patients. Zoloft works for the majority of patients with major depression, have a peek at this site panic disorder and obsessive compulsive disorder (OCD). It may also be prescribed off-label for bulimia nervosa, Vardenafil sale post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder.