Zoloft is a type of antidepressant known as a selective serotonin reuptake inhibitor, or SSRI. It was the first in its class of drugs to be approved by the FDA, cost of motrin without insurance and has been prescribed to over 50 million people since its release in 1992. The active ingredient in Zoloft modulates the action of serotonin (a naturally occurring chemical in your brain that influences your mood) on brain cells. This helps improve symptoms cost of motrin without insurance depression (such as sadness and low energy), panic disorder , obsessive compulsive disorder, social anxiety disorder , and premenstrual dysphoric disorder .