Zoloft (sertraline) hydrochloride is an antidepressant used to treat depression, panic disorder and obsessive-compulsive disorder (OCD). It belongs Allergic reaction to amoxicillin symptoms the class of drugs called selective serotonin reuptake inhibitors (SSRIs), which block the reabsorption of serotonin by certain nerve cells in the brain. As a result, this helps boost the levels of serotonin available in the brain.