Zoloft is an antidepressant that is used to treat depression, promethazine mdr anxiety and obsessive compulsive disorder. It is a selective serotonin reuptake inhibitor (SSRI) which help to increase the amount of serotonin available in the brain. Zoloft produces fewer side effects than older antidepressants called tricyclics, promethazine mdr such as Elavil and Tofranil.